Momelotiniba CAS 1056634-68-4

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Produkta apraksts

Produkta nosaukums: Momelotinib CAS Nr .: 1056634-68-4

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Sinonīmi:

N - (ciānmetil) - 4 - (2 - ((4 - morfolinofenil) - amino) pirimidīns - 4 - il) benzamīds;

N - (ciānmetil) - 4 - (2 - {[4 - (4 - morfolinil) fenil] amino] amino} {{ 0}} 4 - pirimidinil) benzamīda;

Benzamīds, N - (ciānmetil) - 4 - [2 - [[4 - (4 - morfolinil) fenil] amino] - 4 - pirimidinil] -;

Momelotinibs;

CYT387;

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Chemical & amp; Physical Properties

Izskats: Bāli brūns, ciets.

Tests: ≥ 98. 0%

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CYT387 ir Janus kināžu JAK1 un JAK2 inhibitors, kas darbojas kā ATP konkurents ar attiecīgi IC50 vērtībām 11 un 18 nM. Inhibitors ir ievērojami mazāk aktīvs pret citām kināzēm, ieskaitot JAK3 (IC50= 0. 16 μM).

As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions.

The drug was originally discovered by Australian drug discovery company Cytopia, then developed by YM BioSciences Inc. (since acquired by Gilead Sciences as of 2013).

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Populāri tagi: momelotinib cas 1056634-68-4, ražotāji, piegādātāji, rūpnīca, pērciet, noliktavā

• Pāri: Momelotiniba （HCl） CAS 1380317-28-1
• Nākamo: Metil (S)- -2-amino-3-(3-(metilsulfonil) fenil) propanoāta hidrohlorīda CAS 851785-21-2